SPONSORED ADVERTISING CONTENT
PCOS Informer
SPONSORED ADVERTISING CONTENT
The Whistle Blown on the best inositol supplements to support PCOS in the USA
Researched & Posted by
Hannah Wylie*
Last updated on
Last updated on
Expert Reviewed
Evidence Based
*PCOS Informer is made up of the views and opinions of our beauty and nutrition expert Hannah Wylie. The scoring is determined at his own discretion and should not be used for accuracy purposes. We are able to provide this service for free thanks to the referral fees we receive from a number of service providers along with an ownership stake in one or more of the brands. These referral fees may affect the rankings and score assigned to specific vendors. Disclaimer: Furthermore, though many vendors appear on the PCOS Informer, this DOES NOT imply endorsement of any kind and the results of using such products may vary. The information and vendors which appear on PCOS Informer is subject to change at any time.
*PCOS Informer is made up of the views and opinions of our beauty and nutrition expert Hannah Wylie. The scoring is determined at his own discretion and should not be used for accuracy purposes. We are able to provide this service for free thanks to the referral fees we receive from a number of service providers along with an ownership stake in one or more of the brands. These referral fees may affect the rankings and score assigned to specific vendors. Disclaimer: Furthermore, though many vendors appear on the PCOS Informer, this DOES NOT imply endorsement of any kind and the results of using such products may vary. The information and vendors which appear on PCOS Informer is subject to change at any time.
Advertiser Disclosure
Which inositol supplements should you buy?
With countless different inositol supplements vying for your attention, how do you really know which one will actually deliver on their big promises of regulating cycle health, improving insulin sensitivity and boosting fertility?
There are several household brands, some backed by celebrity influencers use expensive PR and marketing to sell their products however if you open up the hood and look at whats underneath do the products match up to the claims they are making?
That’s why we’re here. We researched the top selling inositol supplements on the internet and made purchases to test some of 2024’s most talked about products. We combed through the scientific research.
Why do we need to take inositol for PCOS?
For women with PCOS, clinical research has shown that the ovaries are rich in D-Chiro Inositol. On the other hand, women without PCOS typically have follicular fluid rich in Myo-Inositol.
But why does this happen?
In women with PCOS, imbalanced insulin levels lead to the conversion of myo-inositol into excessive d-chiro inositol. This leads to PCOS symptoms related to cycle health: from irregular cycles, through to egg quality.
This also impacts androgen levels and related skin health and weight challenges caused by excess insulin.
Interestingly, studies have shown that supplementing a combination of D-Chiro and Myo Inositol in a 40:1 ratio proves to have significantly better results than either inositol by itself.1
This includes studied benefits for:
- Ovulation
- Regular Cycles
- Egg Quality
- Metabolism and weight support.2
Insulin response of polycystic ovary syndrome (PCOS) patients (n = 42) to oral glucose load (OGTT) in baseline conditions (□) and after 8 weeks of myo-inositol (MYO) administration
So if all we’ve got to do is take inositol why do I need to continue reading this article right? If only it were that simple…
Supporting insulin levels naturally can be extremely difficult and finding the right inositol can be extremely challenging.
Finding the right product with a therapeutic dose of natural substances to support insulin levels is key.
BEWARE: Not All Inositol Supplements Are Equal
In the course of our research, we discovered a few things the supplement industry probably wishes we’d keep under wraps. Including how:
Many inositol supplements have very little of the high-doses of nutrients you need to truly make an impact
And how many inositol supplements are not delivered in the right ratios to have the best effect on PCOS.
In fact, many of the products we researched have the potential to worsen your symptoms.
Here’s what to look for in inositol vitamins to naturally support insulin levels…
and what you MUST AVOID at all costs.
Must Haves
Therapeutic Doses:
Ensure that you are taking a product with therapeutic levels of the right ingredients.5
40:1 Ratio of Myo:D-Chiro Inositol:
A minimum of 2000mg of myo and 50mg of d-chiro inositol is critical for results8
Taste:
Look for either capsules or flavor-free powders to ensure you can stay dedicated to your routine.
Clearly labeled ingredients:
Many products try to hide their ingredients or have 'patented formulas' to try to hide their ingredients. Transparency is key'
Must Avoid
Gummies:
Gummies almost never have therapeutic dosages and are often heavy sugar.5
Low dosages:
Look for significant dosages - we've done the work for you below by recommending high-dose products 3
Libido boosting supplements:
Many products marketed as 'Libido Boosting' also produce excess testosterone and worsen symptoms. 7
Our Research Backed 10-Point Approach
In addition to our ‘Must Haves’ and ‘Must Avoids’, we have a dedicated ‘Evaluations Team’ that compares and ranks each tested product according to a Research-Backed 10-Point System. We want you to know how our ranking system works:
- 1
Potentially harmful or toxic materials.
- 2
Ingredient quality and ability to affect insulin levels.
- 3
Regulated manufacturing protocols and facilities.
- 4
Absorption of ingredients.
- 5
The research and development of the key ingredient's impact on insulin.
- 6
Cost analysis.
- 7
Country of origin. Made in the USA.
- 8
Returns policy and money back guarantee.
- 9
Customer satisfaction. Differentiating between real and fake customer reviews.
- 10
Benefits of other ingredients.
How We Picked Our Top Choice – A Guide To Our Rankings:
In addition to our ‘Must Haves’ and ‘Must Avoids’, we have a dedicated ‘Evaluations Team’ that compares and ranks each tested collagen product according to a Research-Backed 10-Point System. We want you to know how our ranking system works:
94
Hours of
Scientific Research
11
Hours of
Expert Consultations
52
Customers
Interviewed
Evaluation Criteria
Taste & Ease of Use
Value
Results
Synergistic Ingredients
Company Reputation
Expert Reviewed
Evidence Based
Ingredient Quality
9.8/10
Ingredient Potency
9.6/10
Value
9.4/10
Returns Policy
10/10
Overall Customer Happiness
9.6/10
A+ Rating
9.7
Total Ranking
PROS
101-day money back guarantee (no questions asked)
Therapeutic doses of myo & d-chiro inositol
40:1 Ratio
Made in USA in FDA & GMP Approved facility
Encapsulated powder - can be mixed into drinks or taken as a capsule
CONS
Currently only available online
Out of stock occasionally
The Bottom Line
Cycle Regulate + Ovulate by Nourished Natural Health has been voted #1 by our nutrition expert Hannah Wylie*, with a 9.7 out of 10 score.
What We Loved
Nourished Natural Health was the only brand researched that had the 40:1 myo:d-chiro inositol needed for optimal results. They are afforable and encapsulated so you can have them as a powder or capsule in a therapeutic dose.
Nourished Natural Health is the only company offering a “No questions asked” 101-day money Back Guarantee.
There’s just one small thing…Nourished Natural Health is a small company right now, so they don’t have massive inventory like other “household-name” vitamin brands.
That’s why when people find out about Nourished Natural Health's Cycle Regulate + Ovulate 40:1 Inositol, their inventory sells out fast.
But if you’re reading this page, then you might be in luck. Nourished Natural Health let us know they set aside part of their recent shipment specifically for this review.
However, it’s likely they will sell out of their current inventory within the next 24 hours.
Expert Reviewed
Evidence Based
Ingredient Quality
8.2/10
Ingredient Potency
9.1/10
Value
6.5/10
Returns Policy
6.0/10
Overall Customer Happiness
8.4/10
B Rating
7.9
Total Ranking
PROS
40:1 Myo:D-Chiro Ratio
USA company
Well known brand
Good customer reviews
CONS
Only available as a powder
Only available in a large tub
Expensive
No returns through Amazon
Ingredient Quality
8.6/10
Ingredient Potency
8.9/10
Value
5.0/10
Returns Policy
5.0/10
Overall Customer Happiness
8.0/10
C Rating
7.0
Total Ranking
PROS
Folate and vitamin D included
Vegan
CONS
No Money-Back-Guarantee
Expert Reviewed
Evidence Based
Ingredient Quality
7.6/10
Ingredient Potency
4.5/10
Value
4.8/10
Returns Policy
5.0/10
Overall Customer Happiness
8.1/10
D+ Rating
6.0
Total Ranking
PROS
Made in USA
Vegan
CONS
Contains some things that are not good for PCOS
Expert Reviewed
Evidence Based
Ingredient Quality
7.9/10
Ingredient Potency
7.1/10
Value
4.0/10
Returns Policy
5.0/10
Overall Customer Happiness
7.9/10
D Rating
5.5
Total Ranking
PROS
High dose myo-inositol
CONS
Only contains Myoinositol (not D-Chiro)
Average customer reviews
SOURCES & CITATIONS
🎓[1] Nestler, J.E.; Unfer, V. Reflections on Inositol(s) for PCOS Therapy: Steps toward Success. Gynecol. Endocrinol. 2015, 31, 501–505
🎓[2] Facchinetti, F.; Orrù, B.; Grandi, G.; Unfer, V. Short-Term Effects of M**tformin and Myo-Inositol in Women with Polycystic Ovarian Syndrome (PCOS): A Meta-Analysis of Randomized Clinical Trials. Facchinetti F1, Orrù B2, Grandi G1, Unfer V3. Gynecol. Endocrinol. 2019, 35, 198–206
🎓[3] Laganà, A.S.; Rossetti, P.; Buscema, M.; La Vignera, S.; Condorelli, R.A.; Gullo, G.; Granese, R.; Triolo, O. Metabolism and Ovarian Function in PCOSWomen: ATherapeutic Approach with Inositols. Int. J. Endocrinol. 2016, 2016, 6306410.
🎓[4] Unfer V, Carlomagno G, Papaleo E, Vailati S, Candiani M, Baillargeon JP. Hyperinsulinemia Alters Myoinositol to d-chiroinositol Ratio in the Follicular Fluid of Patients With PCOS. Reprod Sci. 2014;21(7):854-8.
🎓[5] Unfer, V.; Facchinetti, F.; Orrù, B.; Giordani, B.; Nestler, J. Myo-Inositol Effects in Women with PCOS: A Meta-Analysis of Randomized Controlled Trials. Endocr. Connect. 2017, 6, 647–658.
🎓[6] Benelli, E.; Del Ghianda, S.; Di Cosmo, C.; Tonacchera, M. A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. Int. J. Endocrinol. 2016, 2016, 3204083
🎓[7] Bevilacqua, A.; Carlomagno, G.; Gerli, S.; Oliva, M.M.; Devroey, P.; Lanzone, A.; Soulange, C.; Facchinetti, F.; Di Renzo, G.C.; Bizzarri, M.; et al. Results from the International Consensus Conference on Myo-Inositol and D-Chiro-Inositol in Obstetrics and Gynecology-Assisted Reproduction Technology. Gynecol. Endocrinol. 2015, 31, 441–446.
🎓[8] Colazingari, S.; Treglia, M.; Najjar, R.; Bevilacqua, A. The Combined Therapy Myo-Inositol plus D-Chiro-Inositol, Rather than D-Chiro-Inositol, Is Able to Improve IVF Outcomes: Results froma Randomized Controlled Trial. Arch. Gynecol. Obstet. 2013, 288, 1405–1411.
🎓[9] Ravanos K, Monastra G, Pavlidou T, Goudakou M, Prapas N. Can high levels of D-chiro-inositol in follicular fluid exert detrimental effects on blastocyst quality? European review for medical and pharmacological sciences. 2017;21(23):5491-8.
🎓[10] Dinicola, S.; Chiu, T.T.Y.; Unfer, V.; Carlomagno, G.; Bizzarri, M. The Rationale of the Myo-Inositol and D-Chiro-Inositol Combined Treatment for Polycystic Ovary Syndrome. J. Clin. Pharmacol. 2014, 54, 1079–1092
🎓[11] Bevilacqua, A.; Dragotto, J.; Giuliani, A.; Bizzarri, M. Myo-Inositol and D-Chiro-Inositol (40:1) Reverse
Histological and Functional Features of Polycystic Ovary Syndrome in a Mouse Model. J. Cell. Physiol. 2019,
234, 9387–9398.
🎓[12] Diamanti-Kandarakis, E.; Dunaif, A. Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications. Endocr. Rev. 2012, 33, 981–1030.
🎓[13] Abdel Hamid AMS, Ismail Madkour WA, Borg TF. Inositol versus M*****min administration in polycystic ovary syndrome patients: a case–control study. Journal of Evidence-Based Women’s Health Journal Society. 2015;5(3). https://journals.lww.com/ebjwh/Fulltext/2015/08000/Inositol_versus_***_administration_in.2.aspx
PCOS-Informer.com
© 2024 PCOS-Informer.com. All Rights Reserved.
As an Amazon Associate & Affiliate of other partners PCOS Informer may earn a commission from qualifying purchases made as a result of our reviews.
This site is a free online resource that strives to offer helpful content and comparison features to its visitors. Please be advised that the operator of this site accepts advertising compensation from companies that appear on the site and also owns one or more of the brands listed, and such compensation impacts the location and order in which the companies (and/or their products) are presented, and in some cases may also impact the rating that is assigned to them. To the extent that ratings appear on this site, such rating is determined by our subjective opinion and based on a methodology that aggregates our analysis of brand market share and reputation, each brand’s conversion rates, compensation paid to us and general consumer interest. Company listings on this page DO NOT imply endorsement. Except as expressly set forth in our Terms of Use, all representations and warranties regarding the information presented on this page are disclaimed. The information, including pricing, which appears on this site is subject to change at any time.
The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a health care provider. These statements have not been evaluated by the Food and Drug Administration or the European Food Safety Authority. These products are not intended to diagnose, treat, cure, or prevent any diseases or medical conditions. Results are based on the PCOS Informer Ranking System and do not necessarily reflect typical results from the use of these products. Trademarks used on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship PCOS Informer has with our top picks. Please visit product websites for more information. We have a financial relationship with some of our product picks / product partners.